by Springer .
Written in English
|The Physical Object|
|Number of Pages||134|
S. Quackenbush, in Aquaculture Virology, Zebrafish Endogenous Retrovirus. Endogenous retroviruses have been identified in a wide range of vertebrates. These retroviruses are integrated into germ line cells and in most cases have acquired an accumulation of mutations and genetic deletions over time to become transcriptionally inactive. The newest volume in the Current Topics in Microbiology and Immunology series edited by Dr. Vogt and dealing with oncogenes and retroviruses contains four review articles by international authorities in the field. These articles presenting the latest research results continue the tradition of excellence for which the series is so well known. The discovery of viral oncogenes in retroviruses led to the finding that they are not unique to viruses and homologous genes (called proto-oncogenes) are found in all cells. Indeed, it is likely that the virus picked up a cellular gene during its evolution and this gene has subsequently become altered. An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels.. Most normal cells will undergo a programmed form of rapid cell death when critical functions are altered and cyrusofficial.comted oncogenes can cause those cells designated for apoptosis to survive and proliferate instead.
Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host cell. Members of this family include important pathogens such as HIV-1, feline leukemia, and several cancer-causing viruses. The way in which retroviruses cause tumor formation via oncogenes was established before anything was known about how DNA tumor viruses cause tumors. Certainly, DNA tumor viruses carry oncogenes (e.g. SV40 T-antigen) but how do these proteins, encoded in true viral genes with no cellular homologs, cause the formation of tumors? Retroviruses that cause tumor growth include Rous sarcoma virus and Mouse mammary tumor virus. Cancer can be triggered by proto-oncogenes that were mistakenly incorporated into proviral DNA or by the disruption of cellular proto-oncogenes. Rous sarcoma virus contains the src gene that triggers tumor formation. Later it was found that a similar Class: incertae sedis. Retroviruses comprise a large and diverse family of enveloped RNA viruses defined by common taxonomic denominators that include structure, composition, and replicative properties (Coffin a,b, ).The virions are 80– nm in diameter, and their outer lipid envelope incorporates and displays the viral glycoproteins ().Cited by: 4.
Retroviruses have provided some of the most-important insights into the molecular cell biology of cancer (see Retroviruses and the discovery of oncogenes), and yet only one human retrovirus, the human T-cell leukemia virus type I (HTLV-I), is linked to a human tumour. This virus is. Retroviruses: Molecular Biology, Genomics and Pathogenesis [Reinhard Kurth, Norbert Bannert] on cyrusofficial.com *FREE* shipping on qualifying offers. Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host Price: $ Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied. Oncogenes and retroviruses evaluation of basic findings and clinical potential: proceedings of a workshop held at Roswell Park Memorial Institute, Buffalo, New York, September , by Frank J. Rauscher. Published by A.R. Liss in New cyrusofficial.com: